Alma-Jane, an impossibly curious 11-year-old girl who lives in NYC and the most genetically happy person alive, is about to die due to a rare mutation. Ayrton, Alma-Jane’s older brother and a math prodigy, declares war against Death, “the destroyer of Life,” and then suddenly takes off to Oxford, UK, to examine Albert Einstein’s brain. Meanwhile, Death and his younger brother, O.M. (Obituary Man), are overworked and in desperate need of a short vacation.